[HTML][HTML] Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy
CM Trivedi, MM Lu, Q Wang, JA Epstein - Journal of Biological Chemistry, 2008 - ASBMB
Class I and II histone deacetylases (HDACs) play vital roles in regulating cardiac
development, morphogenesis, and hypertrophic responses. Although the roles of Hdac1
and Hdac2, class I HDACs, in cardiac hyperplasia, growth, and hypertrophic responsiveness
have been reported, the role in the heart of Hdac3, another class I HDAC, has been less well
explored. Here we report that myocyte-specific overexpression of Hdac3 in mice results in
cardiac abnormalities at birth. Hdac3 overexpression produces thickening of ventricular …
development, morphogenesis, and hypertrophic responses. Although the roles of Hdac1
and Hdac2, class I HDACs, in cardiac hyperplasia, growth, and hypertrophic responsiveness
have been reported, the role in the heart of Hdac3, another class I HDAC, has been less well
explored. Here we report that myocyte-specific overexpression of Hdac3 in mice results in
cardiac abnormalities at birth. Hdac3 overexpression produces thickening of ventricular …