White adipocytes: more than just fat depots
SL Henry, JG Bensley, RJ Wood-Bradley… - The international journal …, 2012 - Elsevier
The international journal of biochemistry & cell biology, 2012•Elsevier
Globally 30% of adults are overweight or obese. The white adipocyte is a major component
of adipose tissue, and as the obesity epidemic increases it is critically important to
understand the factors determining adipocyte development and function. Adipogenesis has
two distinct phases; determination of the adipocyte from a multipotent stem cell, and terminal
differentiation of a pre-adipocyte into a mature adipocyte. The environment encountered in
early life can alter adipocyte number and size and potentially impact upon adipocyte …
of adipose tissue, and as the obesity epidemic increases it is critically important to
understand the factors determining adipocyte development and function. Adipogenesis has
two distinct phases; determination of the adipocyte from a multipotent stem cell, and terminal
differentiation of a pre-adipocyte into a mature adipocyte. The environment encountered in
early life can alter adipocyte number and size and potentially impact upon adipocyte …
Globally 30% of adults are overweight or obese. The white adipocyte is a major component of adipose tissue, and as the obesity epidemic increases it is critically important to understand the factors determining adipocyte development and function. Adipogenesis has two distinct phases; determination of the adipocyte from a multipotent stem cell, and terminal differentiation of a pre-adipocyte into a mature adipocyte. The environment encountered in early life can alter adipocyte number and size and potentially impact upon adipocyte endocrine function in adulthood. These alterations may contribute to the pathophysiology of chronic diseases and thus targeted therapy of the adipocyte has great potential for treating the current obesity epidemic.
Elsevier