[HTML][HTML] Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth
Osteocrin (Ostn) is a recently discovered secreted protein produced by cells of the
osteoblast lineage that shows a well conserved homology with members of the natriuretic
peptide (NP) family. We hypothesized that Ostn could interact with the NP receptors, thereby
modulating NP actions on the skeleton. Ostn binds specifically and saturably to the NP
peptide receptor-C (NPR-C) receptor with a K d of∼ 5 nm with no binding to the GC-A or GC-
B receptors. Deletion of several of the residues deemed important for NP binding to NPR-C …
osteoblast lineage that shows a well conserved homology with members of the natriuretic
peptide (NP) family. We hypothesized that Ostn could interact with the NP receptors, thereby
modulating NP actions on the skeleton. Ostn binds specifically and saturably to the NP
peptide receptor-C (NPR-C) receptor with a K d of∼ 5 nm with no binding to the GC-A or GC-
B receptors. Deletion of several of the residues deemed important for NP binding to NPR-C …