[HTML][HTML] Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype

G Thomas, P Moffatt, P Salois, MH Gaumond… - Journal of Biological …, 2003 - ASBMB
Although a number of secreted factors have been demonstrated to be bone regulators, none
of these are unique to bone. Using a viral-based signal-trap strategy we have identified a
novel gene we have termed" osteocrin." A 1280-bp mRNA encodes osteocrin producing a
mature protein of 103 amino acids with a molecular mass of 11.4 kDa. Osteocrin shows no
homology with any known gene except for two conserved sequence motifs reminiscent of
dibasic cleavage sites found in peptide hormone precursors. Immunofluorescence and …