[PDF][PDF] Pyroptosis: caspase-11 unlocks the gates of death
A de Gassart, F Martinon - Immunity, 2015 - cell.com
A de Gassart, F Martinon
Immunity, 2015•cell.comHow inflammatory caspases trigger pyroptotic cell death is mostly unexplained. In this issue
of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane
channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-
dependent pyroptosis.
of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane
channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-
dependent pyroptosis.
How inflammatory caspases trigger pyroptotic cell death is mostly unexplained. In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.
cell.com