Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA

NA Wahab, BS Weston, RM Mason - Journal of the American …, 2005 - journals.lww.com
Connective tissue growth factor (CTGF) is implicated as a factor promoting tissue fibrosis in
several disorders, including diabetic nephropathy. However, the molecular mechanism (s)
by which it functions is not known. CTGF rapidly activates several intracellular signaling
molecules in human mesangial cells (HMC), including extracellular signal-related kinase
1/2, Jun NH 2-terminal kinase, protein kinase B, CaMK II, protein kinase Cα, and protein
kinase Cδ, suggesting that it functions via a signaling receptor. Treating HMC with CTGF …