[HTML][HTML] Endoplasmic reticulum stress: cell life and death decisions

C Xu, B Bailly-Maitre, JC Reed - The Journal of clinical …, 2005 - Am Soc Clin Investig
C Xu, B Bailly-Maitre, JC Reed
The Journal of clinical investigation, 2005Am Soc Clin Investig
Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell
stress response, the unfolded protein response, which is aimed initially at compensating for
damage but can eventually trigger cell death if ER dysfunction is severe or prolonged. The
mechanisms by which ER stress leads to cell death remain enigmatic, with multiple potential
participants described but little clarity about which specific death effectors dominate in
particular cellular contexts. Important roles for ER-initiated cell death pathways have been …
Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell stress response, the unfolded protein response, which is aimed initially at compensating for damage but can eventually trigger cell death if ER dysfunction is severe or prolonged. The mechanisms by which ER stress leads to cell death remain enigmatic, with multiple potential participants described but little clarity about which specific death effectors dominate in particular cellular contexts. Important roles for ER-initiated cell death pathways have been recognized for several diseases, including hypoxia, ischemia/reperfusion injury, neurodegeneration, heart disease, and diabetes.
The Journal of Clinical Investigation