Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress
JG Cash, DG Kuhel, JE Basford, A Jaeschke… - Journal of Biological …, 2012 - jbc.org
Apolipoprotein (apo) E4 is a major genetic risk factor for a wide spectrum of inflammatory
metabolic diseases, including atherosclerosis, diabetes, and Alzheimer disease. This study
compared diet-induced adipose tissue inflammation as well as functional properties of
macrophages isolated from human APOE3 and APOE4 mice to identify the mechanism
responsible for the association between apoE4 and inflammatory metabolic diseases. The
initial study confirmed previous reports that APOE4 gene replacement mice were less …
metabolic diseases, including atherosclerosis, diabetes, and Alzheimer disease. This study
compared diet-induced adipose tissue inflammation as well as functional properties of
macrophages isolated from human APOE3 and APOE4 mice to identify the mechanism
responsible for the association between apoE4 and inflammatory metabolic diseases. The
initial study confirmed previous reports that APOE4 gene replacement mice were less …
