The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach
M Aikawa, P Libby - Cardiovascular pathology, 2004 - Elsevier
Vascular inflammation not only plays a major role in the development of coronary
atherosclerosis, but also contributes to the acute onset of thrombotic complications such as
myocardial infarction, a leading cause of death in the United States [1]. Despite a gradual
decrease in age-adjusted mortality attributable to acute myocardial infarction in the United
States, cardiovascular disease is on the rise in many other countries. Macrophage
accumulation and consequent production of proteolytic and thrombogenic molecules …
atherosclerosis, but also contributes to the acute onset of thrombotic complications such as
myocardial infarction, a leading cause of death in the United States [1]. Despite a gradual
decrease in age-adjusted mortality attributable to acute myocardial infarction in the United
States, cardiovascular disease is on the rise in many other countries. Macrophage
accumulation and consequent production of proteolytic and thrombogenic molecules …