[HTML][HTML] Inducible heat shock protein 70 reduces T cell responses and stimulatory capacity of monocyte-derived dendritic cells
P Stocki, XN Wang, AM Dickinson - Journal of biological chemistry, 2012 - ASBMB
Heat shock protein 70 (Hsp70) has gained a lot of attention in the past decade due to its
potential immunoregulatory functions. Some of the described proinflammatory functions of
Hsp70 became controversial as they were based on recombinant Hsp70 proteins
specimens, which were later shown to be endotoxin-contaminated. In this study we used low
endotoxin inducible Hsp70 (also known as Hsp72, HSPA1A), and we observed that after a
24-h incubation of monocyte-derived immature dendritic cells (mo-iDCs) with 20 μg/ml of low …
potential immunoregulatory functions. Some of the described proinflammatory functions of
Hsp70 became controversial as they were based on recombinant Hsp70 proteins
specimens, which were later shown to be endotoxin-contaminated. In this study we used low
endotoxin inducible Hsp70 (also known as Hsp72, HSPA1A), and we observed that after a
24-h incubation of monocyte-derived immature dendritic cells (mo-iDCs) with 20 μg/ml of low …