Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection
D De Feo, A Merlini, C Laterza… - Current opinion in …, 2012 - journals.lww.com
Nowadays, the research on NPC transplantation in neurological disorders is advancing on
two different fronts: on one hand, recent preclinical data are uncovering the molecular basis
of NPC therapeutic plasticity, offering a more solid rational framework for the design of
clinical studies. On the other hand, pilot trials are highlighting the safety and feasibility
issues of neural stem cell transplantation that need to be addressed before efficacy could be
properly evaluated.
two different fronts: on one hand, recent preclinical data are uncovering the molecular basis
of NPC therapeutic plasticity, offering a more solid rational framework for the design of
clinical studies. On the other hand, pilot trials are highlighting the safety and feasibility
issues of neural stem cell transplantation that need to be addressed before efficacy could be
properly evaluated.
Summary
Nowadays, the research on NPC transplantation in neurological disorders is advancing on two different fronts: on one hand, recent preclinical data are uncovering the molecular basis of NPC therapeutic plasticity, offering a more solid rational framework for the design of clinical studies. On the other hand, pilot trials are highlighting the safety and feasibility issues of neural stem cell transplantation that need to be addressed before efficacy could be properly evaluated.
Lippincott Williams & Wilkins