[HTML][HTML] The acute respiratory distress syndrome

MA Matthay, LB Ware… - The Journal of clinical …, 2012 - Am Soc Clin Investig
MA Matthay, LB Ware, GA Zimmerman
The Journal of clinical investigation, 2012Am Soc Clin Investig
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory
failure that is often associated with multiple organ failure. Several clinical disorders can
precipitate ARDS, including pneumonia, sepsis, aspiration of gastric contents, and major
trauma. Physiologically, ARDS is characterized by increased permeability pulmonary
edema, severe arterial hypoxemia, and impaired carbon dioxide excretion. Based on both
experimental and clinical studies, progress has been made in understanding the …
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory failure that is often associated with multiple organ failure. Several clinical disorders can precipitate ARDS, including pneumonia, sepsis, aspiration of gastric contents, and major trauma. Physiologically, ARDS is characterized by increased permeability pulmonary edema, severe arterial hypoxemia, and impaired carbon dioxide excretion. Based on both experimental and clinical studies, progress has been made in understanding the mechanisms responsible for the pathogenesis and the resolution of lung injury, including the contribution of environmental and genetic factors. Improved survival has been achieved with the use of lung-protective ventilation. Future progress will depend on developing novel therapeutics that can facilitate and enhance lung repair.
The Journal of Clinical Investigation