Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitis
O Einstein, D Karussis, N Grigoriadis… - Molecular and Cellular …, 2003 - Elsevier
Brain transplantation of neural precursor cells (NPCs) has been proposed to enhance CNS
regeneration. As the pathogenesis of most acute CNS diseases involves an inflammatory
component, we studied whether NPC transplantation affects brain inflammation. Newborn
rat multipotential NPCs were transplanted intraventriculary into acute experimental allergic
encephalomyelitis (EAE) rats, a model for disseminated brain inflammation. Cells migrated
into inflamed white matter and differentiated into glial cells. NPC transplantation attenuated …
regeneration. As the pathogenesis of most acute CNS diseases involves an inflammatory
component, we studied whether NPC transplantation affects brain inflammation. Newborn
rat multipotential NPCs were transplanted intraventriculary into acute experimental allergic
encephalomyelitis (EAE) rats, a model for disseminated brain inflammation. Cells migrated
into inflamed white matter and differentiated into glial cells. NPC transplantation attenuated …