Alport's syndrome, Goodpasture's syndrome, and type IV collagen

BG Hudson, K Tryggvason… - … England Journal of …, 2003 - Mass Medical Soc
New England Journal of Medicine, 2003Mass Medical Soc
Defects in type IV collagen, a collagenous protein involved in the formation of basement
membranes, have been implicated in hereditary Alport's syndrome and acquired
Goodpasture's syndrome. Mutations in genes corresponding to the building blocks of type IV
collagen cause Alport's syndrome, whereas autoantibodies against structures that are
usually hidden in the recesses of collagen IV cause Goodpasture's syndrome.
Defects in type IV collagen, a collagenous protein involved in the formation of basement membranes, have been implicated in hereditary Alport's syndrome and acquired Goodpasture's syndrome. Mutations in genes corresponding to the building blocks of type IV collagen cause Alport's syndrome, whereas autoantibodies against structures that are usually hidden in the recesses of collagen IV cause Goodpasture's syndrome.
The New England Journal Of Medicine