[HTML][HTML] Loss of small heterodimer partner expression in the liver protects against dyslipidemias⃞
HB Hartman, KD Lai, MJ Evans - Journal of lipid research, 2009 - ASBMB
Multiple studies suggest increased conversion of cholesterol to bile acids by cholesterol 7α-
hydroxylase (CYP7A1) protects against dyslipidemia and atherosclerosis. CYP7A1
expression is repressed by the sequential activity of two nuclear hormone receptors,
farnesoid X receptor (FXR) and small heterodimer partner (SHP). Here we demonstrate 129
strain SHP−/− mice are protected against hypercholesterolemia resulting from either a
cholesterol/cholic acid (chol/CA) diet or from hypothyroidism. In a mixed 129-C57Bl/6 …
hydroxylase (CYP7A1) protects against dyslipidemia and atherosclerosis. CYP7A1
expression is repressed by the sequential activity of two nuclear hormone receptors,
farnesoid X receptor (FXR) and small heterodimer partner (SHP). Here we demonstrate 129
strain SHP−/− mice are protected against hypercholesterolemia resulting from either a
cholesterol/cholic acid (chol/CA) diet or from hypothyroidism. In a mixed 129-C57Bl/6 …