Contribution of MicroRNAs to autoimmune diseases

LP Garo, G Murugaiyan - Cellular and Molecular Life Sciences, 2016 - Springer
LP Garo, G Murugaiyan
Cellular and Molecular Life Sciences, 2016Springer
MicroRNAs are a class of evolutionarily conserved, short non-coding RNAs that post-
transcriptionally modulate the expression of multiple target genes. They are implicated in
almost every biological process, including pathways involved in immune homeostasis, such
as immune cell development, central and peripheral tolerance, and T helper cell
differentiation. Alterations in miRNA expression and function can lead to major dysfunction
of the immune system and mediate susceptibility to autoimmune disease. Here, we discuss …
Abstract
MicroRNAs are a class of evolutionarily conserved, short non-coding RNAs that post-transcriptionally modulate the expression of multiple target genes. They are implicated in almost every biological process, including pathways involved in immune homeostasis, such as immune cell development, central and peripheral tolerance, and T helper cell differentiation. Alterations in miRNA expression and function can lead to major dysfunction of the immune system and mediate susceptibility to autoimmune disease. Here, we discuss the role of miRNAs in the maintenance of immune tolerance to self-antigens and the gain or loss of miRNA functions on tissue inflammation and autoimmunity.
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