Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance
AM Bilate, JJ Lafaille - Annual review of immunology, 2012 - annualreviews.org
Regulatory T lymphocytes are essential to maintain homeostasis of the immune system,
limiting the magnitude of effector responses and allowing the establishment of
immunological tolerance. Two main types of regulatory T cells have been identified—natural
and induced (or adaptive)—and both play significant roles in tuning down effector immune
responses. Adaptive CD4+ Foxp3+ regulatory T (iTreg) cells develop outside the thymus
under a variety of conditions. These include not only antigen presentation under …
limiting the magnitude of effector responses and allowing the establishment of
immunological tolerance. Two main types of regulatory T cells have been identified—natural
and induced (or adaptive)—and both play significant roles in tuning down effector immune
responses. Adaptive CD4+ Foxp3+ regulatory T (iTreg) cells develop outside the thymus
under a variety of conditions. These include not only antigen presentation under …