[CITATION][C] TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
TR Mosmann, RL Coffman - Annual review of immunology, 1989 - annualreviews.org
Effector functions in the immune system are carried out by a variety of cell types, and as our
understanding of the complexity of the system expands, the number of recognized
subdivisions of cell types also continues to increase. B lymphocytes, producing antibody,
were initially disн tinguished from T lymphocytes, which provide help for B cells (1, 2). The T-
cell population was further divided when surface markers allowed separation of helper cells
from cytotoxic cells (3). Although there were persistent reports of heterogeneity in the helper …
understanding of the complexity of the system expands, the number of recognized
subdivisions of cell types also continues to increase. B lymphocytes, producing antibody,
were initially disн tinguished from T lymphocytes, which provide help for B cells (1, 2). The T-
cell population was further divided when surface markers allowed separation of helper cells
from cytotoxic cells (3). Although there were persistent reports of heterogeneity in the helper …