Lysyl oxidase (LOX) is an enzyme responsible for the cross-linking of collagen and elastin
both in vitro andin vivo. The unique functions of the individual members of this multigene
family have been difficult to ascertain because of highly conserved catalytic domains and
overlapping tissue expression patterns. To address this problem of functional and structural
redundancy and to determine the role of LOX in the development of tissue integrity, Lox
gene expression was deleted by targeted mutagenesis in mice. Lox-targeted mice (LOX−/−) …