[HTML][HTML] Lysyl hydroxylase 2 is secreted by tumor cells and can modify collagen in the extracellular space
Y Chen, H Guo, M Terajima, P Banerjee, X Liu… - Journal of Biological …, 2016 - ASBMB
Abstract Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysine residues in the
telopeptides of fibrillar collagens, which leads to the formation of stable collagen cross-links.
Recently we reported that LH2 enhances the metastatic propensity of lung cancer by
increasing the amount of stable hydroxylysine aldehyde-derived collagen cross-links
(HLCCs), which generate a stiffer tumor stroma (Chen, Y., et al.(2015) J. Clin. Invest. 125,
125, 1147–1162). It is generally accepted that LH2 modifies procollagen α chains on the …
telopeptides of fibrillar collagens, which leads to the formation of stable collagen cross-links.
Recently we reported that LH2 enhances the metastatic propensity of lung cancer by
increasing the amount of stable hydroxylysine aldehyde-derived collagen cross-links
(HLCCs), which generate a stiffer tumor stroma (Chen, Y., et al.(2015) J. Clin. Invest. 125,
125, 1147–1162). It is generally accepted that LH2 modifies procollagen α chains on the …