[HTML][HTML] LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size
H Okazaki, JL Goldstein, MS Brown, G Liang - Journal of biological …, 2010 - ASBMB
Liver X receptors (LXRs) activate triglyceride synthesis in liver directly and indirectly by
inducing sterol regulatory element-binding protein-1c (SREBP-1c). When administered to
wild-type mice, the LXR activator T0901317 produces a mild and transient
hypertriglyceridemia. Here, we show that T0901317 produces massive hypertriglyceridemia
when given to mice lacking low density lipoprotein (LDL) receptors (Ldlr−/− mice).
Triglycerides ranged from 4000 to 6000 mg/dl, and the plasma turned milky. The median …
inducing sterol regulatory element-binding protein-1c (SREBP-1c). When administered to
wild-type mice, the LXR activator T0901317 produces a mild and transient
hypertriglyceridemia. Here, we show that T0901317 produces massive hypertriglyceridemia
when given to mice lacking low density lipoprotein (LDL) receptors (Ldlr−/− mice).
Triglycerides ranged from 4000 to 6000 mg/dl, and the plasma turned milky. The median …