[HTML][HTML] Two signaling mechanisms for activation of αMβ2 avidity in polymorphonuclear neutrophils
Circulating polymorphonuclear neutrophils (PMN) are quiescent, nonadherent cells that
rapidly activate at sites of inflammation, where they develop the capacity to perform a
repertoire of functions that are essential for host defense. Induction of integrin-mediated
adhesion, which requires an increase in integrin avidity, is critical for the development of
these effector functions. Although a variety of stimuli can activate integrins in PMN, the
signaling cascades involved are unclear. Phosphatidylinositol (PI) 3-kinase has been …
rapidly activate at sites of inflammation, where they develop the capacity to perform a
repertoire of functions that are essential for host defense. Induction of integrin-mediated
adhesion, which requires an increase in integrin avidity, is critical for the development of
these effector functions. Although a variety of stimuli can activate integrins in PMN, the
signaling cascades involved are unclear. Phosphatidylinositol (PI) 3-kinase has been …