The infiltration of neutrophils and monocytes is a prominent feature of inflammatory diseases
including human rheumatoid arthritis. Understanding how neutrophil recruitment is
regulated during pathogenesis is crucial for developing anti-inflammatory therapies. We
optimized the K/B× N serum-induced mouse arthritis model to study neutrophil trafficking
dynamics in vivo using two-photon microscopy. Arthritogenic serum was injected
subcutaneously into one hind footpad to induce a local arthritis with robust neutrophil …