Overcoming pharmacologic sanctuaries
TJ Cory, TW Schacker, M Stevenson… - Current opinion in HIV …, 2013 - journals.lww.com
TJ Cory, TW Schacker, M Stevenson, CV Fletcher
Current opinion in HIV and AIDS, 2013•journals.lww.comNew strategies for increasing antiretroviral concentrations in predominant sites of viral
replication may provide more effective means for elimination of viral sanctuaries. Additional
research is necessary to optimize antiretroviral tissue distribution in order to inhibit virus
replication fully, and avoid resistance and replenishment of viral reservoirs that may persist
in the face of antiretroviral therapy.
replication may provide more effective means for elimination of viral sanctuaries. Additional
research is necessary to optimize antiretroviral tissue distribution in order to inhibit virus
replication fully, and avoid resistance and replenishment of viral reservoirs that may persist
in the face of antiretroviral therapy.
Summary
New strategies for increasing antiretroviral concentrations in predominant sites of viral replication may provide more effective means for elimination of viral sanctuaries. Additional research is necessary to optimize antiretroviral tissue distribution in order to inhibit virus replication fully, and avoid resistance and replenishment of viral reservoirs that may persist in the face of antiretroviral therapy.
Lippincott Williams & Wilkins