[HTML][HTML] Regulation of TGFβ1-mediated collagen formation by LOX-1: studies based on forced overexpression of TGFβ1 in wild-type and Lox-1

C Hu, A Dandapat, L Sun, JA Khan, Y Liu… - Journal of biological …, 2008 - ASBMB
Transforming growth factor β 1 (TGFβ 1) activation leads to tissue fibrosis. Here, we report
on the role of LOX-1, a lectin-like 52-kDa receptor for oxidized low density lipoprotein, in
TGFβ 1-mediated collagen expression and underlying signaling in mouse cardiac
fibroblasts. TGFβ 1 was overexpressed in wild-type (WT) and LOX-1 knock-out mouse
cardiac fibroblasts by transfection with adeno-associated virus type 2 vector carrying the
active TGFβ 1 moiety (AAV/TGFβ ACT 1). Transfection of WT mouse cardiac fibroblasts with …