Variation in the human TP53 gene affects old age survival and cancer mortality
D van Heemst, SP Mooijaart, M Beekman… - Experimental …, 2005 - Elsevier
Longevity may depend on a balance between tumor suppression and tissue renewal
mechanisms [Campisi, J., 2003. Cancer and ageing: rival demons? Nat. Rev. Cancer 3 (5),
339–349]. Mice with constitutively activated p53 are almost cancer free but their life span is
reduced and accompanied by early tissue atrophy [Tyner et al., 2002. p53 mutant mice that
display early ageing-associated phenotypes. Nature 415 (6867), 45–53]. Replacement of
arginine (Arg) by proline (Pro) at position 72 of human p53 decreases its apoptotic potential …
mechanisms [Campisi, J., 2003. Cancer and ageing: rival demons? Nat. Rev. Cancer 3 (5),
339–349]. Mice with constitutively activated p53 are almost cancer free but their life span is
reduced and accompanied by early tissue atrophy [Tyner et al., 2002. p53 mutant mice that
display early ageing-associated phenotypes. Nature 415 (6867), 45–53]. Replacement of
arginine (Arg) by proline (Pro) at position 72 of human p53 decreases its apoptotic potential …