Autoimmune T cell responses in the central nervous system

J Goverman - Nature Reviews Immunology, 2009 - nature.com
J Goverman
Nature Reviews Immunology, 2009nature.com
Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by
two distinct lineages of CD4+ T cells that are defined by the production of either interferon-γ
or interleukin-17. The activity of these CD4+ T cell subsets within the CNS influences the
pathology and clinical course of disease. New animal models show that myelin-specific
CD8+ T cells can also mediate CNS autoimmunity. This Review focuses on recent progress …
Abstract
Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by two distinct lineages of CD4+ T cells that are defined by the production of either interferon-γ or interleukin-17. The activity of these CD4+ T cell subsets within the CNS influences the pathology and clinical course of disease. New animal models show that myelin-specific CD8+ T cells can also mediate CNS autoimmunity. This Review focuses on recent progress in delineating the pathogenic mechanisms, regulation and interplay between these different T cell subsets in CNS autoimmunity.
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