Pericytes play pivotal roles in physiological and pathophysiological conditions in the central
nervous system. As pericytes prevent vascular leakage, they can halt neuronal damage
stemming from a compromised blood-brain barrier. Therefore, pericytes may be a good
target for the treatment of neurodegenerative disorders, although evidence is lacking. In this
study, we show that prostacyclin attenuates lysophosphatidylcholine (LPC)-mediated
vascular dysfunction through pericyte protection in the adult mouse spinal cord. LPC …