PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways
W Baron, B Metz, R Bansal, D Hoekstra… - Molecular and Cellular …, 2000 - Elsevier
In this paper we address the linking of platelet-derived growth factor (PDGF) and basic
fibroblast growth factor (FGF-2) to intracellular signaling molecules in oligodendrocyte
progenitors. It is demonstrated that both growth factors activate downstream targets similar to
those shown for protein kinase C (PKC) activation. Yet, neither the arrest of terminal
oligodendrocyte differentiation nor the proliferation induced by PDGF or FGF-2 can be
antagonized by inhibition of PKC. Rather, p42/p44 mitogen-activated protein kinase (MAPK) …
fibroblast growth factor (FGF-2) to intracellular signaling molecules in oligodendrocyte
progenitors. It is demonstrated that both growth factors activate downstream targets similar to
those shown for protein kinase C (PKC) activation. Yet, neither the arrest of terminal
oligodendrocyte differentiation nor the proliferation induced by PDGF or FGF-2 can be
antagonized by inhibition of PKC. Rather, p42/p44 mitogen-activated protein kinase (MAPK) …