Metabolism of stromal and immune cells in health and disease

B Ghesquière, BW Wong, A Kuchnio, P Carmeliet - Nature, 2014 - nature.com
Nature, 2014nature.com
Cancer cells have been at the centre of cell metabolism research, but the metabolism of
stromal and immune cells has received less attention. Nonetheless, these cells influence the
progression of malignant, inflammatory and metabolic disorders. Here we discuss the
metabolic adaptations of stromal and immune cells in health and disease, and highlight how
metabolism determines their differentiation and function.
Abstract
Cancer cells have been at the centre of cell metabolism research, but the metabolism of stromal and immune cells has received less attention. Nonetheless, these cells influence the progression of malignant, inflammatory and metabolic disorders. Here we discuss the metabolic adaptations of stromal and immune cells in health and disease, and highlight how metabolism determines their differentiation and function.
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