Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice

I Obara, KK Tochiki, SM Géranton, FB Carr, BM Lumb… - Pain, 2011 - Elsevier
The management of neuropathic pain is unsatisfactory, and new treatments are required.
Because the sensitivity of a subset of fast-conducting primary afferent nociceptors is thought
to be regulated by the mammalian target of rapamycin complex 1 (mTORC1) signaling
pathway, selectively targeting mTORC1 represents a new strategy for the control of chronic
pain. Here we show that activated mTOR was expressed largely in myelinated sensory
fibers in mouse and that inhibiting the mTORC1 pathway systemically alleviated mechanical …