Transforming growth factor β3 attenuates the development of radiation-induced pulmonary fibrosis in mice by decreasing fibrocyte recruitment and regulating IFN-γ/IL …
L Xu, S Xiong, R Guo, Z Yang, Q Wang, F Xiao… - Immunology letters, 2014 - Elsevier
Radiation-induced pulmonary fibrosis is a frequently occurred complication from
radiotherapy of thoracic tumors. The transforming growth factor-β (TGF-β) superfamily plays
a key regulatory role in pulmonary fibrosis. As TGF-β3 showed the potential anti-fibrotic
properties especially in scar-less wound healing as opposed to the fibrotic function of TGF-
β1, we sought to explore the role of TGF-β3 in radiation-induced pulmonary fibrosis. A single
thoracic irradiation of 20 Gy was applied in mice to establish the model of radiation-induced …
radiotherapy of thoracic tumors. The transforming growth factor-β (TGF-β) superfamily plays
a key regulatory role in pulmonary fibrosis. As TGF-β3 showed the potential anti-fibrotic
properties especially in scar-less wound healing as opposed to the fibrotic function of TGF-
β1, we sought to explore the role of TGF-β3 in radiation-induced pulmonary fibrosis. A single
thoracic irradiation of 20 Gy was applied in mice to establish the model of radiation-induced …