Epithelial cytokines and pulmonary allergic inflammation

CM Lloyd, S Saglani - Current opinion in immunology, 2015 - Elsevier
Current opinion in immunology, 2015Elsevier
Highlights•The triad of cytokines, IL-25, IL-33 and TSLP, play a defined role in allergic
inflammation at mucosal surfaces.•The precise function of these cytokines during human
allergic disease is variable.•These cytokines exert a particular effect during more severe
disease.•These cytokines have therapeutic potential for patients with more severe disease
with established remodelling and resistant to conventional drugs.The triad of epithelial
derived cytokines, IL-25, IL-33 and TSLP are important for the initiation and development of …
Highlights
  • The triad of cytokines, IL-25, IL-33 and TSLP, play a defined role in allergic inflammation at mucosal surfaces.
  • The precise function of these cytokines during human allergic disease is variable.
  • These cytokines exert a particular effect during more severe disease.
  • These cytokines have therapeutic potential for patients with more severe disease with established remodelling and resistant to conventional drugs.
The triad of epithelial derived cytokines, IL-25, IL-33 and TSLP are important for the initiation and development of pulmonary immune responses to environmental stimuli. Data from experiments using mouse models provide compelling evidence for their involvement in both innate and adaptive immunity to drive type-2 responses, allergic inflammation and airway remodelling. These cytokines are known to be expressed in human lung tissue and immune cells, however their involvement in mediating allergic pulmonary responses in patients is less clear than in murine models of disease. This article focuses on evidence for the role of IL-25, IL-33 and TSLP in human allergic disease and discusses their potential as therapeutic targets for severe asthma.
Elsevier