Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease
M Fuhrmann, T Bittner, CKE Jung, S Burgold… - Nature …, 2010 - nature.com
M Fuhrmann, T Bittner, CKE Jung, S Burgold, RM Page, G Mitteregger, C Haass, FM LaFerla…
Nature neuroscience, 2010•nature.comMicroglia, the immune cells of the brain, can have a beneficial effect in Alzheimer's disease
by phagocytosing amyloid-β. Two-photon in vivo imaging of neuron loss in the intact brain of
living Alzheimer's disease mice revealed an involvement of microglia in neuron elimination,
indicated by locally increased number and migration velocity of microglia around lost
neurons. Knockout of the microglial chemokine receptor Cx3cr1, which is critical in neuron-
microglia communication, prevented neuron loss.
by phagocytosing amyloid-β. Two-photon in vivo imaging of neuron loss in the intact brain of
living Alzheimer's disease mice revealed an involvement of microglia in neuron elimination,
indicated by locally increased number and migration velocity of microglia around lost
neurons. Knockout of the microglial chemokine receptor Cx3cr1, which is critical in neuron-
microglia communication, prevented neuron loss.
Abstract
Microglia, the immune cells of the brain, can have a beneficial effect in Alzheimer's disease by phagocytosing amyloid-β. Two-photon in vivo imaging of neuron loss in the intact brain of living Alzheimer's disease mice revealed an involvement of microglia in neuron elimination, indicated by locally increased number and migration velocity of microglia around lost neurons. Knockout of the microglial chemokine receptor Cx3cr1, which is critical in neuron-microglia communication, prevented neuron loss.
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