Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
F Alliot, I Godin, B Pessac - Developmental Brain Research, 1999 - Elsevier
Microglia, the resident CNS macrophages, represent about 10% of the adult brain cell
population. Although described a long time ago, their origin and developmental lineage is
still debated. While del Rio-Hortega suggested that microglia originate from meningeal
macrophages penetrating the brain during embryonic development, many authors claim that
brain parenchymal microglia derive from circulating blood monocytes originating from bone
marrow. We have previously reported that the late embryonic and adult mouse brain …
population. Although described a long time ago, their origin and developmental lineage is
still debated. While del Rio-Hortega suggested that microglia originate from meningeal
macrophages penetrating the brain during embryonic development, many authors claim that
brain parenchymal microglia derive from circulating blood monocytes originating from bone
marrow. We have previously reported that the late embryonic and adult mouse brain …