Fibrin (ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12
Background & Aims Acetaminophen (APAP)-induced liver injury is coupled with activation of
the blood coagulation cascade and fibrin (ogen) accumulation within APAP-injured livers of
experimental mice. We sought to define the role of fibrin (ogen) deposition in APAP-induced
liver injury and repair. Methods Wild-type, fibrinogen-deficient mice, mutant mice with fibrin
(ogen) incapable of binding leukocyte α M β 2 integrin (Fibγ 390-396A mice) and matrix
metalloproteinase 12 (Mmp12)-deficient mice were fasted, injected with 300 mg/kg APAP ip …
the blood coagulation cascade and fibrin (ogen) accumulation within APAP-injured livers of
experimental mice. We sought to define the role of fibrin (ogen) deposition in APAP-induced
liver injury and repair. Methods Wild-type, fibrinogen-deficient mice, mutant mice with fibrin
(ogen) incapable of binding leukocyte α M β 2 integrin (Fibγ 390-396A mice) and matrix
metalloproteinase 12 (Mmp12)-deficient mice were fasted, injected with 300 mg/kg APAP ip …