[HTML][HTML] Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial

MC Liu, LM Dubé, J Lancaster… - Journal of Allergy and …, 1996 - Elsevier
Background: Leukotrienes produced by the 5-lipoxygenase pathway of arachidonic acid
metabolism may mediate bronchoconstriction and inflammatory changes important in the
pathophysiology of asthma. Leukotriene inhibition may be effective in asthma management.
Objective: This clinical trial was performed to assess the long-term efficacy and safety of
zileuton, an inhibitor of 5-lipoxygenase. Methods: In this multicenter, double-blind, parallel-
group, placebo-controlled trial, 600 mg of zileuton, 400 mg of zileuton, or placebo was given …