High capacity for leukotriene biosynthesis in peripheral blood during pregnancy
AM Schaible, A Koeberle, H Northoff, B Lawrenz… - … and Essential Fatty …, 2013 - Elsevier
Pregnancy is accompanied by major immunological changes to maintain both tolerance for
the fetus and immune competence. Leukotrienes are powerful 5-lipoxygenase-derived
inflammatory mediators and the characteristics of leukotriene-related diseases (eg, asthma,
allergic rhinitis) change during pregnancy. Here, we show that pregnancy affects leukotriene
synthesis in human blood and leukocytes. 5-Lipoxygenase product formation in stimulated
blood of pregnant women was significantly higher than in non-pregnant females. Although a …
the fetus and immune competence. Leukotrienes are powerful 5-lipoxygenase-derived
inflammatory mediators and the characteristics of leukotriene-related diseases (eg, asthma,
allergic rhinitis) change during pregnancy. Here, we show that pregnancy affects leukotriene
synthesis in human blood and leukocytes. 5-Lipoxygenase product formation in stimulated
blood of pregnant women was significantly higher than in non-pregnant females. Although a …