[HTML][HTML] Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV …

K Bartholomeeusen, K Fujinaga, Y Xiang… - Journal of Biological …, 2013 - ASBMB
Numerous studies have looked at the effects of histone deacetylase inhibitors (HDACis) on
HIV reactivation in established transformed cell lines and primary CD4+ T cells. However,
their findings remain confusing, and differences between effects of class I-and class II-
specific HDACis persist. Because no clear picture emerged, we decided to determine how
HDACis reactivate HIV in transformed cell lines and primary cells. We found that neither
histone H3 nor tubulin acetylation correlated with HIV reactivation in Jurkat and HeLa cells …