Bruton's tyrosine kinase is activated upon CD40 stimulation in human B lymphocytes

C Brunner, A Avots, HW Kreth, E Serfling, V Schuster - Immunobiology, 2002 - Elsevier
Bruton's tyrosine kinase (Btk) is known to be involved in a broad array of signal transduction
pathways necessary for the proliferation, survival and development of B cells. Mutations in
the Btk gene are causually linked to the development of X-linked agammaglobulinemia
(XLA) in humans. We show here, that CD40 ligation leads to tyrosine phosphorylation of Btk
in the human immature B cell line MHH-PREB-1. Even though the CD40-mediated tyrosine
phosphorylation of Btk is less efficient than that mediated through the B cell receptor, CD40 …