[PDF][PDF] SnapShot: Fanconi anemia and associated proteins
AT Wang, A Smogorzewska - Cell, 2015 - cell.com
Cell, 2015•cell.com
Fanconi anemia is a genetic disorder resulting from biallelic mutations in one of the 17
FANC genes. It is characterized by congenital abnormalities, bone marrow failure, and
cancer predisposition. The underlying cause is genomic instability resulting from the
deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly
referred to as the Fanconi anemia-BRCA pathway. This SnapShot presents the key factors
involved.
FANC genes. It is characterized by congenital abnormalities, bone marrow failure, and
cancer predisposition. The underlying cause is genomic instability resulting from the
deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly
referred to as the Fanconi anemia-BRCA pathway. This SnapShot presents the key factors
involved.
Fanconi anemia is a genetic disorder resulting from biallelic mutations in one of the 17 FANC genes. It is characterized by congenital abnormalities, bone marrow failure, and cancer predisposition. The underlying cause is genomic instability resulting from the deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly referred to as the Fanconi anemia-BRCA pathway. This SnapShot presents the key factors involved.
cell.com