Interferon-gamma (IFNγ) is a cytokine that plays physiologically important roles in promoting
innate and adaptive immune responses. The absence of IFNγ production or cellular
responsiveness in humans and experimental animals significantly predisposes the host to
microbial infection, a result that validates the physiologic importance of this cytokine in
preventing infectious disease. Recently, an additional role for IFNγ in preventing
development of primary and transplanted tumors has been identified. Although there now …