Rapid regression of atherosclerosis with MTP inhibitor treatment
B Hewing, S Parathath, CK Mai, MI Fiel, L Guo… - Atherosclerosis, 2013 - Elsevier
OBJECTIVE: Regression of atherosclerosis is a vital treatment goal of atherosclerotic
vascular disease. Inhibitors of the microsomal triglyceride transfer protein (MTP) have been
shown to reduce apolipoprotein B (apoB)-containing lipoproteins in animals and humans
effectively. Therefore, the major aim of our study is to evaluate the effect of MTP inhibition on
atherosclerotic plaque regression. METHODS: LDL-receptor-deficient (LDLr−/−) mice were
fed a Western diet for 16 weeks and then harvested for baseline (n= 8), switched to chow …
vascular disease. Inhibitors of the microsomal triglyceride transfer protein (MTP) have been
shown to reduce apolipoprotein B (apoB)-containing lipoproteins in animals and humans
effectively. Therefore, the major aim of our study is to evaluate the effect of MTP inhibition on
atherosclerotic plaque regression. METHODS: LDL-receptor-deficient (LDLr−/−) mice were
fed a Western diet for 16 weeks and then harvested for baseline (n= 8), switched to chow …