[HTML][HTML] Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire
M van Lummel, PA van Veelen, A Zaldumbide… - Journal of Biological …, 2012 - ASBMB
HLA-DQ2 and HLA-DQ8 are strongly predisposing haplotypes for type 1 diabetes (T1D). Yet
HLA-DQ2/8 heterozygous individuals have a synergistically increased risk compared with
HLA-DQ2 or HLA-DQ8 homozygote subjects that may result from the presence of a
transdimer formed between the α-chain of HLA-DQ2 (DQA1* 05: 01) and the β-chain of HLA-
DQ8 (DQB1* 03: 02). We generated cells exclusively expressing this transdimer (HLA-
DQ8trans), characterized its peptide binding repertoire, and defined a unique transdimer …
HLA-DQ2/8 heterozygous individuals have a synergistically increased risk compared with
HLA-DQ2 or HLA-DQ8 homozygote subjects that may result from the presence of a
transdimer formed between the α-chain of HLA-DQ2 (DQA1* 05: 01) and the β-chain of HLA-
DQ8 (DQB1* 03: 02). We generated cells exclusively expressing this transdimer (HLA-
DQ8trans), characterized its peptide binding repertoire, and defined a unique transdimer …