CHOP is a critical regulator of acetaminophen-induced hepatotoxicity

D Uzi, L Barda, V Scaiewicz, M Mills, T Mueller… - Journal of …, 2013 - Elsevier
Background & Aims The liver is a major site of drug metabolism and elimination and as such
is susceptible to drug toxicity. Drug induced liver injury is a leading cause of acute liver
injury, of which acetaminophen (APAP) is the most frequent causative agent. APAP toxicity is
initiated by its toxic metabolite NAPQI. However, downstream mechanisms underlying APAP
induced cell death are still unclear. Endoplasmic reticulum (ER) stress and the unfolded
protein response (UPR) have recently emerged as major regulators of metabolic …