Protein phosphatase 2A regulatory subunits and cancer
PJA Eichhorn, MP Creyghton, R Bernards - Biochimica et Biophysica Acta …, 2009 - Elsevier
PJA Eichhorn, MP Creyghton, R Bernards
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2009•ElsevierThe serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an
integral role in the regulation of a number of major signaling pathways whose deregulation
can contribute to cancer. The specificity and activity of PP2A are highly regulated through
the interaction of a family of regulatory B subunits with the substrates. Accumulating
evidence indicates that PP2A acts as a tumor suppressor. In this review we summarize the
known effects of specific PP2A holoenzymes and their roles in cancer relevant pathways. In …
integral role in the regulation of a number of major signaling pathways whose deregulation
can contribute to cancer. The specificity and activity of PP2A are highly regulated through
the interaction of a family of regulatory B subunits with the substrates. Accumulating
evidence indicates that PP2A acts as a tumor suppressor. In this review we summarize the
known effects of specific PP2A holoenzymes and their roles in cancer relevant pathways. In …
The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an integral role in the regulation of a number of major signaling pathways whose deregulation can contribute to cancer. The specificity and activity of PP2A are highly regulated through the interaction of a family of regulatory B subunits with the substrates. Accumulating evidence indicates that PP2A acts as a tumor suppressor. In this review we summarize the known effects of specific PP2A holoenzymes and their roles in cancer relevant pathways. In particular we highlight PP2A function in the regulation of MAPK and Wnt signaling.
Elsevier