Modulation of Cav1. 3 Ca2+ channel gating by Rab3 interacting molecule

M Gebhart, G Juhasz-Vedres, A Zuccotti… - Molecular and Cellular …, 2010 - Elsevier
Neurotransmitter release and spontaneous action potentials during cochlear inner hair cell
(IHC) development depend on the activity of Cav1. 3 voltage-gated L-type Ca2+ channels.
Their voltage-and Ca2+-dependent inactivation kinetics are slower than in other tissues but
the underlying molecular mechanisms are not yet understood. We found that Rab3-
interacting molecule-2α (RIM2α) mRNA is expressed in immature cochlear IHCs and the
protein co-localizes with Cav1. 3 in the same presynaptic compartment of IHCs. Expression …