Pulmonary hypertension: anatomic and physiologic correlates

B Meyrick, L Reid - Clinics in chest medicine, 1983 - Elsevier
The types of pulmonary arterial hypertension described here all focus attention on the
changes produced in the lung's microcirculation, particularly the precapillary unit. Although
one senses intuitively that obliteration of resistance arteries is an effective cause of
hypertension, we emphasize that cell metaplasia and adaptation by structural remodeling of
the precapillary arterial wall is also effective in reducing the vascular bed. A question often
asked is whether “pruning” is the cause of the hypertension… perhaps an inappropriate …