Applications of small molecule BMP inhibitors in physiology and disease

CC Hong, BY Paul - Cytokine & growth factor reviews, 2009 - Elsevier
Bone morphogenetic proteins (BMPs) provide critical signals for determining cell fate,
specifying gastrulation, embryonic patterning, organogenesis, and the remodeling of diverse
tissues. Recent work has suggested that in addition to coordinating pivotal events in
development, BMPs may also regulate certain homeostatic physiological processes
independently of effects on cell growth or differentiation. We recently described the
identification of dorsomorphin, a small molecule inhibitor of BMP type I receptors which …