[HTML][HTML] Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice

T Furuyama, K Kitayama, Y Shimoda, M Ogawa… - Journal of Biological …, 2004 - ASBMB
Members of the Foxo family, Foxo1 (Fkhr), Foxo3 (Fkhrl1), and Foxo4 (Afx), are mammalian
homologs of daf-16, which influences life span and energy metabolism in Caenorhabditis
elegans. Mammalian FOXO proteins also play important roles in cell cycle arrest, apoptosis,
stress resistance, and energy metabolism. In this study, we generated Foxo1-deficient mice
to investigate the physiological role of FOXO1. The Foxo1-deficient mice died around
embryonic day 11 because of defects in the branchial arches and remarkably impaired …